Investigation of the relationship between the data of cardio specific autoantibodies ANTI-ACTC1, ANTI-MYH7B, ANTI-сTnl and electrocardiogram results at early stage of diagnosis of myocardial damage

The aim of the study was to assess the relationship between the levels of Anti-ACTC1, Anti-MYH7B and Anti-cTnI autoantibodies in blood serum with the electrocardiogram results in athletes undergoing intense physical exercise in order to predict adverse cardiovascular events. Materials and Methods . This work included a medical examination of two groups of men aged 18–22 years (n=15) and 18–25 years (n=20) with different amounts of total motor activity. The study was conducted in accordance with the recommendations for a stage medical examination of cyclists, which includes the determination of the anti-ACTC1, anti-MYH7B, anti-cTnI levels in blood serum. Results . Intense physical exertion and psychoemotional stress activate the immune response and increase the severity of serum antibodies increases. In particular, there is a significant increase in antibody expression: Anti-ACTC1 by 18.0%, Anti-MYH7B by 20.1%, Anti-cTnI by 40.9% (p<0.01). In addition to the expression of antibodies to contractile apparatus proteins, there are electrocardiographic abnormalities (p>0.05): violation of the processes of cardiac repolarization and ventricular conduction, ST segment elevation, the QRS complex elongation by 17.0%, the QT interval shortening by 27.5% and corrected QT (QTc) by 30.3%, as well as the PQ interval prolongation by 15.0%. Conclusion . Considering the increase in the autoantibody levels during physical exertion, this can be considered as an early indicator of myocytes and cardiomyocytes damage during physical overload.