Safety, tolerability, and efficacy outcomes of the Investigation of Levetiracetam in Alzheimer's disease (ILiAD) study: a pilot, double‐blind placebo‐controlled crossover trial
Abnormal electrical activity within the brain, such as is seen in seizures, might contribute to memory problems in people with dementia. We completed a clinical trial to see if an antiseizure medication, levetiracetam, could help with memory difficulties in people with Alzheimer's disease (the most common cause of dementia). In this pilot study, we could not prove whether levetiracetam helped memory function. We did show that the drug is safe and well tolerated in people with dementia who have not had a seizure. This work, therefore, offers a platform for future research exploring antiseizure medications in people with dementia.
Authors
- Mkael Symmonds (ORCID: https://orcid.org/0000-0001-9903-5083)
- Sergio Mura
- Ivan Koychev (ORCID: https://orcid.org/0000-0001-6813-8493)
- Gabriel Davis Jones (ORCID: https://orcid.org/0000-0003-4070-4814)
- Joanne Galloway
- Sanjay Manohar (ORCID: https://orcid.org/0000-0003-0735-4349)
- Christopher Butler (ORCID: https://orcid.org/0000-0002-7502-9284)
- Mary Akinola
- Masud Husain (ORCID: https://orcid.org/0000-0002-6850-9255)
- Rupert McShane (ORCID: https://orcid.org/0000-0002-3272-5984)
- Jane Chan
- Raquel Maio
- Rohan Van Der Putt
- Sharon Love (ORCID: https://orcid.org/0000-0002-6695-5390)
- Arjune Sen (ORCID: https://orcid.org/0000-0002-8948-4763)
- Sian Thompson
- Sofia Toniolo (ORCID: https://orcid.org/0000-0002-1833-4995)
- John Geddes (ORCID: https://orcid.org/0000-0002-5281-5960)
- Xin You Tai (ORCID: https://orcid.org/0000-0001-8911-2559)
- Younes Adam Tabi (ORCID: https://orcid.org/0000-0002-6561-130X)
- Eleni Frangou (ORCID: https://orcid.org/0000-0002-5978-292X)
- Angela Hallam
Institutions
- Nuffield Orthopaedic Centre (GB)
- Oxford Health NHS Foundation Trust (GB)
- John Radcliffe Hospital (GB)
- Warneford Hospital (GB)
- Christian-Albrechts-Universität zu Kiel (DE)
- University of Oxford (GB)
- MRC Clinical Trials Unit at UCL (GB)
- Health Foundation (GB)
- UCB Pharma (United Kingdom) (GB)
- University College London (GB)
- Imperial College London (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/epi4.13070
- Citations
- 11
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- Medical Research Council
- UCB Pharma