Association between gastroprotective agents and acute kidney injury in patients receiving non‐steroidal anti‐inflammatory drugs: Analysis of a Japanese hospital‐based database
Compared with H2RAs, PPIs may increase the risk of AKI in patients receiving NSAIDs, although no statistically significant difference was observed. Further research is required to assess the risk trade-off with consideration of both peptic ulcer prevention and the increased risk of AKI in patients concurrently treated with NSAIDs and H2RAs, misoprostol, or PPIs.
Authors
- Shungo Imai (ORCID: https://orcid.org/0000-0001-5706-613X)
- Hayato Kizaki (ORCID: https://orcid.org/0000-0002-4572-1333)
- Satoru Mitsuboshi (ORCID: https://orcid.org/0000-0002-6244-1253)
- Satoko Hori (ORCID: https://orcid.org/0000-0002-4596-5418)
Institutions
- Keio University (JP)
- Kaetsu University (JP)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/phar.4617
- Citations
- 2
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology