Spatial Multiomics Reveals Intratumoral Immune Heterogeneity with Distinct Cytokine Networks in Lung Cancer Brain Metastases
Immune cell signatures are conserved across lung cancer brain metastases, and immune-metastatic tumor cell networks have a prognostic effect, implying that targeting cytokine networks between immune and metastatic tumor cells may generate more precise immunotherapeutic approaches.
Authors
- Julhash Uddin Kazi (ORCID: https://orcid.org/0000-0002-0719-5336)
- Gustav Christensson (ORCID: https://orcid.org/0009-0001-3968-218X)
- Hugo González Velozo (ORCID: https://orcid.org/0000-0003-2183-3637)
- Kristian Pietras (ORCID: https://orcid.org/0000-0001-6738-4705)
- Catharina Hagerling (ORCID: https://orcid.org/0000-0001-5631-7988)
- Matteo Bocci (ORCID: https://orcid.org/0000-0002-8774-0006)
- Geoffroy Durand (ORCID: https://orcid.org/0000-0001-9004-7248)
- Gustav Lanzing
Institutions
- University of California, San Francisco (US)
- Lund University (SE)
- Fundación Ciencia and Vida (CL)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0201
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.84