Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis
Our study demonstrates that PUS7 promotes the inhibition of CD47 and inhibits metastasis of PTC cells by regulating the ψ modification of pre-miR-8082. These results suggest that PUS7 and ψ pre-miR-8082 may serve as potential targets and diagnostic markers for PTC metastasis.
Authors
- Donge Tang (ORCID: https://orcid.org/0000-0001-7011-196X)
- Wenjun Pu (ORCID: https://orcid.org/0000-0001-6243-9762)
- Xunpeng Luo
- Yong Dai
- Zhipeng Zeng (ORCID: https://orcid.org/0000-0003-3609-9287)
- Hengyuan Gao
- Xi Wang (ORCID: https://orcid.org/0000-0001-8417-8583)
- Nan Xu (ORCID: https://orcid.org/0000-0003-0531-7958)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Southern University of Science and Technology (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s12935-024-03482-3
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.64