Withaferin A: the potent anti-cancer agent from Ashwagandha

For ages, the medicinal plant Withania somnifera, also known as Ashwagandha, has been an essential component of Ayurvedic medicine. It is well documented that components of WS have anti-inflammatory, immunomodulatory, analgesic, and anti-cancer properties. WS is composed of 14 anolides, of which Withaferin A (WA) is the most significant. WA, a steroidal lactone, impedes oncogenic signaling and induces apoptosis in a cancer cell. Previously, we have documented the potency of WA in breast cancer, prostate cancer, and colon cancer. A significant efficacy of WA against the breast cancer stem cell population, a key cell population accountable for chemoresistance, has been documented. Withaferin A targets a multitude of oncoproteins and cell cycle checkpoints and augments the activity of anticancer drugs, thus gaining ground as a promising anticancer molecule. Owing to its strong anti-cancer potential, WA should be a center of focus for the scientific community because of its translational value in the modern medicine system. Additionally, scientific investigation is needed to comprehend WA’s pharmacokinetics and bioavailability. In the present review article, we have comprehensively included the molecular targets of WA in various neoplasms.

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Publication Details

Journal
Minerva Biotechnology and Biomolecular Research
Published
2024-10-01
DOI
https://doi.org/10.23736/s2724-542x.24.03124-9
Citations
3
Primary Topic
Phytochemicals and Medicinal Plants
Type
article
Field-Weighted Citation Impact
2.15
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article

Withaferin A: the potent anti-cancer agent from Ashwagandha

Rashmi Singh, Manisha Gupta, Bikash Medhi, Ujjawal Sharma et al.
3 citations
Minerva Biotechnology and Biomolecular Research
Phytochemicals and Medicinal Plants
2.15
article

Withaferin A: the potent anti-cancer agent from Ashwagandha

Rashmi Singh, Manisha Gupta, Bikash Medhi, Ujjawal Sharma, Dharambir Kashyap, Shafiul Haque, Phulen Sarma, Aman Sharma, Deeksha Pal, Vivek Kumar Garg, Hardeep Singh Tuli, Ashutosh Singh
article en
3 citations

Abstract

For ages, the medicinal plant Withania somnifera, also known as Ashwagandha, has been an essential component of Ayurvedic medicine. It is well documented that components of WS have anti-inflammatory, immunomodulatory, analgesic, and anti-cancer properties. WS is composed of 14 anolides, of which Withaferin A (WA) is the most significant. WA, a steroidal lactone, impedes oncogenic signaling and induces apoptosis in a cancer cell. Previously, we have documented the potency of WA in breast cancer, prostate cancer, and colon cancer. A significant efficacy of WA against the breast cancer stem cell population, a key cell population accountable for chemoresistance, has been documented. Withaferin A targets a multitude of oncoproteins and cell cycle checkpoints and augments the activity of anticancer drugs, thus gaining ground as a promising anticancer molecule. Owing to its strong anti-cancer potential, WA should be a center of focus for the scientific community because of its translational value in the modern medicine system. Additionally, scientific investigation is needed to comprehend WA’s pharmacokinetics and bioavailability. In the present review article, we have comprehensively included the molecular targets of WA in various neoplasms.

Minerva Biotechnology and Biomolecular ResearchVol. 36(3)
Chandigarh University (IN), Central University of Punjab (IN), Indiana University Health (US), Maharishi Markandeshwar University, Mullana (IN), Ajman University (AE), Delhi Pharmaceutical Science and Research University (IN), Fistulacure (IN), Indiana Cancer Consortium (US), All India Institute of Medical Sciences Guwahati (IN), Post Graduate Institute of Medical Education and Research (IN), Indiana University – Purdue University Indianapolis (US), Jazan University (SA)
Clean water and sanitation
Openalex Percentile: Top 12%
Phytochemicals and Medicinal Plants
2.15
DOISourceOpenAlex
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