Effects of BYL-719 (alpelisib) on human breast cancer stem cells to overcome drug resistance in human breast cancer
The 3D cell culture is a novel and highly effective method for enriching BCSCs <i>in vitro</i>. Furthermore, the stemness and EMT of BCSCs were inhibited by BYL-719 by acting on various signaling pathways. Finally, we believe that drug resistance can be overcome by targeting the BCSCs. Conjugation of BYL-719 with other anti-neoplastic agents may be a promising treatment for this in clinic.
Authors
- Yuanchun Ye (ORCID: https://orcid.org/0000-0002-1514-2605)
- Jan Eucker (ORCID: https://orcid.org/0000-0002-6714-8056)
- Leinan Yu
- Hongyu Liu (ORCID: https://orcid.org/0009-0002-6718-7976)
- Chuanbing Zang
Institutions
- Sun Yat-sen University (CN)
- Humboldt-Universität zu Berlin (DE)
- Vivantes Klinikum (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.3389/fphar.2024.1443422
- Citations
- 5
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.41