iPSC-derived megakaryocytes and platelets accelerate wound healing and angiogenesis
Our study demonstrates that iMPs promote angiogenesis and wound healing through the activation of vascular endothelial cells. iMPs exhibited more effectiveness than PRP, an effect attributed to the exclusive presence of specific factors including FGF2. Lyophilization enabled the long-term maintenance of the composition of the growth factors and efficacy of the iMPs, therefore contributing to stable supply for clinical application. These findings suggest that iMPs provide a novel treatment for chronic wounds.
Authors
- Michiaki Mukai (ORCID: https://orcid.org/0000-0002-4673-4734)
- Bahityar Rahmutulla (ORCID: https://orcid.org/0000-0002-4014-2789)
- Ikuko Tajiri (ORCID: https://orcid.org/0000-0002-2627-091X)
- Nobuyuki Mitsukawa (ORCID: https://orcid.org/0000-0002-0234-8241)
- Masaki Fukuyo
- Atsushi Iwama (ORCID: https://orcid.org/0000-0001-9410-8992)
- Koji Eto (ORCID: https://orcid.org/0000-0002-5863-7122)
- Shinsuke Akita (ORCID: https://orcid.org/0000-0001-7075-6602)
- Kentaro Kosaka (ORCID: https://orcid.org/0009-0002-6858-9870)
- Sudip Kumar Paul (ORCID: https://orcid.org/0009-0000-3131-0042)
- Nobutaka Furuyama
- Yoshitaka Kubota (ORCID: https://orcid.org/0000-0002-4821-365X)
- Atsushi Kaneda (ORCID: https://orcid.org/0000-0002-6980-5515)
- Maria Alejandra Kanashiro (ORCID: https://orcid.org/0009-0006-0689-9717)
- Naoya Takayama (ORCID: https://orcid.org/0000-0001-6867-1677)
- Motohiko Oshima (ORCID: https://orcid.org/0000-0002-3963-0013)
Institutions
- Chiba University (JP)
- Kyoto University (JP)
- Hoshigaoka Medical Center (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s13287-024-03966-z
- Citations
- 9
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.82
Funders
- Japan Society for the Promotion of Science