<scp>miR</scp>‐4448/Girdin/Akt/<scp>AMPK</scp> axis inhibits <scp>EZH2</scp>‐mediated <scp>EMT</scp> and tumorigenesis in small‐cell lung cancer
SCLC characterized high EZH2 expression and promoted EMT, compared with non-small cell lung cancer. miR-4448 inhibited Girdin expression, reducing Akt phosphorylation, and enhancing AMPK and EZH2 phosphorylation. Eventually, miR-4448 prevented EZH2-mediated EMT and tumorigenesis by modulating the Girdin/Akt/AMPK axis in SCLC. miR-4448 might be a potential SCLC inhibitor.
Authors
- Nobuyuki Koyama
- Yuichi Ishikawa (ORCID: https://orcid.org/0000-0002-9594-5845)
- Hiroyuki Kyoyama
- Kazutetsu Aoshiba (ORCID: https://orcid.org/0000-0002-9490-9754)
- Kazutsugu Uematsu (ORCID: https://orcid.org/0000-0003-0014-295X)
- Hiromitsu Ohta (ORCID: https://orcid.org/0000-0001-9893-0254)
- Takuya Aoki (ORCID: https://orcid.org/0000-0002-1299-4220)
Institutions
- Jichi Medical University (JP)
- Tokyo Medical University Hachioji Medical Center (JP)
- Tokyo Medical University Ibaraki Medical Center (JP)
- Social Insurance Saitama Chuo Hospital (JP)
- Jichi Medical University Saitama Medical Center (JP)
- International University of Health and Welfare (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/cam4.70093
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Smoking Research Foundation
- Japan Society for the Promotion of Science