Regioselective Intermolecular Hydroamidation of <i>β</i>‐CF<sub>3</sub>‐1,3‐Enynamides: An Approach to Tri‐Substituted <i>γ</i>‐CF<sub>3</sub>‐Allenamides
Abstract A simple base mediated, highly regioselective 1,4‐hydroamidation of β ‐CF 3 ‐1,3‐enynamides with secondary amides for synthesis of tri‐substituted γ ‐CF 3 ‐allenamides compounds was developed. N ‐alkyl sulfonamides are generally good candidates for the present transformation. γ ‐CF 3 ‐allenamides could be employed for synthesis of potential value‐added compounds such as fluorinated halogenated pyrrole, tetrahydroquinoline and 2‐CF 3 ‐putrescine derivatives.
Authors
- Zongxiang Yu
- Yuanjing Xiao (ORCID: https://orcid.org/0000-0002-0185-1961)
- Yizhen Chen (ORCID: https://orcid.org/0000-0002-8499-2013)
- Lu Liu (ORCID: https://orcid.org/0000-0003-2151-891X)
- Yuxuan Cao
Institutions
- East China Normal University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/ejoc.202400674
- Citations
- 6
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality