NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression
Tumor-intrinsic NPM1 promotes tumor immune evasion via suppressing IRF1-mediated antigen presentation to impair tumor immunogenicity and reprogram the immunosuppressive TME. Our study identifies NPM1 as a potential target for improving cancer immunotherapy.
Authors
- Wenkai Zhou (ORCID: https://orcid.org/0000-0002-4622-2384)
- Bingjing Wang
- Jiaying Song
- Xuetao Cao (ORCID: https://orcid.org/0000-0001-9677-7647)
- Quan Yuan (ORCID: https://orcid.org/0000-0001-5487-561X)
- Jiaming Wang (ORCID: https://orcid.org/0000-0001-7881-7158)
- Henan Xu (ORCID: https://orcid.org/0000-0001-7625-6385)
- Yangyang Chai (ORCID: https://orcid.org/0000-0002-3646-7820)
- Xiaoqing Xu (ORCID: https://orcid.org/0000-0001-8294-6307)
- Xin Wang (ORCID: https://orcid.org/0000-0002-6229-1945)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nankai University (CN)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s13045-024-01618-6
- Citations
- 19
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.37
Funders
- National Natural Science Foundation of China