Additive‐Free and Diastereoselective Synthesis for <i>Trans</i>‐Disubstituted‐2,3‐Dihydro‐Benzofurans <i>via</i> [4+1] Annulation between <i>p</i>‐QMs and TFISYs
Abstract An additive‐free and diastereoselective [4+1] annulation between ortho ‐hydroxyphenyl‐substituted para ‐quinone methides and CF 3 ‐substituted imidoyl sulfoxonium ylides is developed, providing a facile and practical route to diverse trans ‐2,3‐dihydrobenzofurans with high efficiency. This protocol features mild conditions, broad substrate scope and easy to operate.
Authors
- Chuan‐Chuan Wang
- Mengru Ren
- Qinglong Wang (ORCID: https://orcid.org/0000-0003-1883-812X)
- Yajing Chen (ORCID: https://orcid.org/0000-0002-1624-0741)
- Yi‐Hui Li
Institutions
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/ejoc.202400946
- Citations
- 3
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Natural Science Foundation of China
- Shanghai University of Traditional Chinese Medicine