Activity Variations of CYP2B6 Determine the Metabolic Stratification of Efavirenz
Variations in liver enzyme activity and CYP2B6 genetic polymorphisms can significantly alter the metabolism of efavirenz. It provides laboratory-based data for the precise application of efavirenz and other CYP2B6 substrate drugs.
Authors
- Xiao-Dan Zhang (ORCID: https://orcid.org/0000-0002-8474-0561)
- Le-Hao Jin
- Xiaoyu Xu (ORCID: https://orcid.org/0000-0002-0327-7369)
- Jing Wang (ORCID: https://orcid.org/0000-0002-7959-0685)
- Yun-shan Zhong (ORCID: https://orcid.org/0009-0000-8653-7359)
- Xinyue Li (ORCID: https://orcid.org/0000-0003-1017-5253)
- Jianchang Qian
- Jing Yuan (ORCID: https://orcid.org/0009-0003-3463-2030)
- Qian Liu (ORCID: https://orcid.org/0000-0001-5341-1290)
Institutions
- Wenzhou Medical University (CN)
- Aerospace Center Hospital (CN)
- Wenzhou City People's Hospital (CN)
Publication Details
- Journal
- Chemical Research in Toxicology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1021/acs.chemrestox.4c00230
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Zhejiang Province
- Natural Science Foundation of Zhejiang Province