Near‐Infrared Activatable Copper Nanoplatforms Synergize with the 5‐Azacytidine Prodrug to Potentiate Cuproptosis
Cuproptosis, a newly discovered cell death modality, is gaining recognition for its crucial role in antitumor therapy. Here, we demonstrated that Ferredoxin 1 (FDX1), a key gene involved in cuproptosis, is negatively correlated with malignancy and T-cell exhaustion in head and neck squamous cell carcinoma (HNSCC). Based on these findings, we developed near-infrared (NIR) light-controlled nanoparticles (NPs), CuD@PM, which can selectively deliver copper to HNSCC cells and induce cuproptosis in the presence of microneedles loaded with triacetylated azacitidine (TAc-AzaC) and 808 nm laser irradiation. Intravenous administration of these NPs significantly suppressed tumor growth in HNSCC animal models and enhanced the antitumor immune response. The NIR-controlled activation of cuproptosis offers great potential as a safe, targeted, and image-guided antitumor therapy for HNSCC.
Authors
- Zhi‐Jun Sun (ORCID: https://orcid.org/0000-0003-0932-8013)
- Wuyin Wang (ORCID: https://orcid.org/0000-0002-9005-7312)
- Wen-Da Wang (ORCID: https://orcid.org/0000-0001-6735-9171)
- Yishen Liu (ORCID: https://orcid.org/0009-0007-0329-0014)
- Zhiyun Zhang (ORCID: https://orcid.org/0000-0002-5944-4429)
- Yuling Xiao (ORCID: https://orcid.org/0000-0003-1237-941X)
- Xuechuan Hong (ORCID: https://orcid.org/0000-0001-6834-3278)
- Qichao Yang (ORCID: https://orcid.org/0000-0002-7957-0772)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-2748-4151)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-9706-091X)
- Mengya Su
Institutions
- Chinese Academy of Sciences (CN)
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Shanghai Institute of Materia Medica (CN)
- Zhongnan Hospital of Wuhan University (CN)
- State Key Laboratory of Virology
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/anie.202411609
- Citations
- 21
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 3.87
Funders
- National Natural Science Foundation of China
- Wuhan University
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province