The Role of BDNF in the Antidepressant Effects of Electroconvulsive Therapy
Electroconvulsive therapy (ECT) is an effective treatment method for depression therapy. It produces a number of biological effects, including neurotrophic factors regulation. In the present paper, we investigated the ECT response in depressed rats subjected to the variable frequency ultrasound (20-45 kHz) and examined the contribution of brain-derived neurotrophic factor (BDNF) expression changes to the observed effects. The obtained results reflect the therapeutic potential of ECT for the treatment of depressive-like state in rodents and indicate the role of BDNF in these processes. In future research, it is necessary to investigate the relationship between neurotrophin and structural changes and to study other neurotrophic biomarkers that may be associated with the development of depression-like state and the therapy response.
Authors
- Аnna Morozova (ORCID: https://orcid.org/0000-0002-8681-5299)
- О. И. Гурина (ORCID: https://orcid.org/0000-0001-6942-5531)
- Eugene Zubkov (ORCID: https://orcid.org/0000-0001-6133-3421)
- Aleksandra Ochneva (ORCID: https://orcid.org/0000-0003-4182-5503)
- Valeriya Ushakova (ORCID: https://orcid.org/0000-0003-3480-910X)
- Olga Abramova (ORCID: https://orcid.org/0000-0001-8793-1833)
- Yana Zorkina (ORCID: https://orcid.org/0000-0003-0247-2717)
- А. Н. Иноземцев (ORCID: https://orcid.org/0000-0002-5059-3241)
- Pavlov Ka (ORCID: https://orcid.org/0000-0001-8390-7000)
- В. П. Чехонин (ORCID: https://orcid.org/0000-0003-4386-7897)
- K. S. Tarkovskaya
Institutions
- Lomonosov Moscow State University (RU)
- Pirogov Russian National Research Medical University (RU)
- Federal Medical Research Centre for Psychiatry and Narcology (RU)
Publication Details
- Journal
- Doklady Biological Sciences
- Published
- 2024-10-11
- DOI
- https://doi.org/10.1134/s0012496624600313
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00