Preparation and Characterization of Anti-Microbial Wound Healing Materials from Natural Origins

Abstract Many types of polymers utilized as wound dressings, Polycaprolactone (PCL) displays high degree of biocompatibility as well as biodegradability, the mechanical strength states PCL in the foreground materials used in wound healing therapies. Current work aims to develop new types of wound plaster dressing, a multiple of natural and medical materials (aloe Vera, calendula and phenobarbital) were used to enhance the anti-microbial behavior as well as pain removal during wound healing period. Aloe Vera gels, Calendula extraction, with phenobarbital drug were precipitates on PCL layer in different percentage. Microstructure observation proves that polycaprolactone polymer is good base material supports dressing constituents, wound dressing homogeneity increased due to chemical reactions between the Aloe Vera and other materials. the main elements of dressing (carbon and oxygen) observed from chemical analysis (EDS) which is also showed that using combination of natural plants (aloe vera and Calendula) with phenobarbital medicine create wound plaster layer with wide range of active elements lead to therapeutic effects including antibacterial, In (FTIR) the results show using mixture of natural additives (aloe, calendula), medicine like phenobarbital in PCL lead to create wound plaster with high (OH) content acts to expedite the skin’s healing process by maintaining the natural level of minerals and hydration at wound area. Hydrophobicity of wound can minimized when adding some hydrophilic materials like Aloe Vera, phenobarbital and calendula, Aloe Vera gel, phenobarbital, as well as calendula decrease the contact angle value. Providing high adhesion between wound plaster and skin tissue. All prepared wound plaster has same and high resistance to Staphylococcus bacteria (40mm).