The cytokine profile correlates with less tumor-infiltrating lymphocytes in luminal A breast cancer
We identified a luminal A-associated immunosuppressive cytokine signature in circulation. These results suggest that a tumor microenvironment with high levels of IL-17 and PDGF-bb, and low levels of MIP-1b in luminal A breast cancers results in low induction of TILs. Our data may partially explain the low TIL levels observed in the patients with luminal A breast cancer.
Authors
- Takako Kihara (ORCID: https://orcid.org/0000-0002-0954-2733)
- Yasuo Miyoshi
- Sayaka Urano
- Miki Komatsu (ORCID: https://orcid.org/0000-0001-5632-6737)
- Seiichi Hirota (ORCID: https://orcid.org/0000-0002-5000-9631)
- Masayuki Nagahashi (ORCID: https://orcid.org/0000-0002-9308-448X)
- Eri Ishikawa (ORCID: https://orcid.org/0000-0003-1623-7996)
- Takahiro Watanabe (ORCID: https://orcid.org/0000-0002-7249-8106)
- Mamiko Kuroiwa
Institutions
- Hyogo Medical University (JP)
- Chibune General Hospital (JP)
- Hyogo University (JP)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1007/s10549-024-07492-7
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Japan Society for the Promotion of Science London
- Daiichi-Sankyo
- Hyogo College of Medicine
- Chugai Pharmaceutical
- Japan Society for the Promotion of Science