BNIP3+ fibroblasts associated with hypoxia and inflammation predict prognosis and immunotherapy response in pancreatic ductal adenocarcinoma
This study revealed the BNIP3+ Fibro subtype associated with hypoxia and inflammatory responses, which was closely related to the poor prognosis of patients with PDAC, and identified signature genes that predict the immunotherapy response in PDAC.
Authors
- Bo Gao (ORCID: https://orcid.org/0000-0001-6161-1903)
- Boshi Sun (ORCID: https://orcid.org/0009-0004-9664-128X)
- Guo‐Hua Hu (ORCID: https://orcid.org/0000-0002-1001-6386)
- Hao Yang (ORCID: https://orcid.org/0009-0005-8623-8531)
- Wenqiang Li (ORCID: https://orcid.org/0009-0002-2593-0194)
Institutions
- Harbin Medical University (CN)
- Peking University (CN)
- Jinshan Hospital of Fudan University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Peking University People's Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s12967-024-05674-x
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Peking University
- Peking University People's Hospital