Mitochondrial disruption resulting from Cepharanthine-mediated TOM inhibition triggers ferroptosis in colorectal cancer cells
In summary, Cep-mediated TOM inhibition inactivates the NRF2 signaling pathway, thereby triggering ferroptosis and achieving an anti-colorectal cancer effect. The current study provides an innovative chemotherapeutic approach for colorectal cancer with phytomedicine.
Authors
- Liu‐Gen Li
- Rong-Cheng Xiao
- Ning Han (ORCID: https://orcid.org/0000-0001-8177-2843)
- Abdul Moiz Qureshi
- Min Yan (ORCID: https://orcid.org/0000-0002-5184-9210)
- Yuan-Jian Hui
- Qi Huang (ORCID: https://orcid.org/0000-0001-8734-1681)
- Jun Hu (ORCID: https://orcid.org/0000-0001-5990-6796)
- Nannan Chen (ORCID: https://orcid.org/0000-0001-5523-4195)
- Fan Leng
- Hui Liu (ORCID: https://orcid.org/0009-0003-3273-6979)
- Di Zhang (ORCID: https://orcid.org/0000-0001-5196-4633)
- Yan Yang (ORCID: https://orcid.org/0009-0006-7177-1111)
Institutions
- Hubei University of Medicine (CN)
- Taihe Hospital (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1007/s00432-024-05974-1
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- Hubei Provincial Department of Education
- Natural Science Foundation of Hubei Province
- Hubei University of Medicine
- Hubei University