Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus

Inhibitory interneurons are pivotal components of cortical circuits. Beyond providing inhibition, they have been proposed to coordinate the firing of excitatory neurons within cell assemblies. While the roles of specific interneuron subtypes have been extensively studied, their influence on pyramidal cell synchrony in vivo remains elusive. Employing an all-optical approach in mice, we simultaneously recorded hippocampal interneurons and pyramidal cells and probed the network influence of individual interneurons using optogenetics. We demonstrate that CA1 interneurons form a functionally interconnected network that promotes synchrony through disinhibition during awake immobility, while preserving endogenous cell assemblies. Our network model underscores the importance of both cell assemblies and dense, unspecific interneuron connectivity in explaining our experimental findings, suggesting that interneurons may operate not only via division of labor but also through concerted activity.

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Publication Details

Journal
PLoS Biology
Published
2024-10-14
DOI
https://doi.org/10.1371/journal.pbio.3002837
Citations
13
Primary Topic
Neuroscience and Neuropharmacology Research
Type
article
Field-Weighted Citation Impact
3.49

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article

Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus

Robin F. Dard, Valentina Emiliani, Sadra Sadeh, Rosa Cossart et al.
13 citations
PLoS Biology
Neuroscience and Neuropharmacology Research
3.49
article

Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus

Robin F. Dard, Valentina Emiliani, Sadra Sadeh, Rosa Cossart, Susanne Reichinnek, Claudia Clopath, Agnès Baude, Marco Bocchio, Sophie Brustlein, Artem Vorobyev
article en
13 citations

Abstract

Inhibitory interneurons are pivotal components of cortical circuits. Beyond providing inhibition, they have been proposed to coordinate the firing of excitatory neurons within cell assemblies. While the roles of specific interneuron subtypes have been extensively studied, their influence on pyramidal cell synchrony in vivo remains elusive. Employing an all-optical approach in mice, we simultaneously recorded hippocampal interneurons and pyramidal cells and probed the network influence of individual interneurons using optogenetics. We demonstrate that CA1 interneurons form a functionally interconnected network that promotes synchrony through disinhibition during awake immobility, while preserving endogenous cell assemblies. Our network model underscores the importance of both cell assemblies and dense, unspecific interneuron connectivity in explaining our experimental findings, suggesting that interneurons may operate not only via division of labor but also through concerted activity.

PLoS BiologyVol. 22(10)
Centre National de la Recherche Scientifique (FR), Institut de la Vision (FR), Inserm (FR), Durham University (GB), Aix-Marseille Université (FR), Sorbonne Université (FR), Imperial College London (GB)
Wellcome Trust, European Commission, Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, Fondation Bettencourt Schueller, Fondation Roger de Spoelberch, Horizon 2020 Framework Programme, European Research Council, H2020 Marie Skłodowska-Curie Actions
Decent work and economic growth
Openalex Percentile: Top 7%
Neuroscience and Neuropharmacology Research
3.49
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