Evaluating Synergistic Effects of Hyaluronic Acid, Human Umbilical Cord-Derived Mesenchymal Stem Cells, and Growth Hormones in Knee Osteoarthritis: A Multi-Arm Randomized Trial
While the combined use of HA, hUC-MSCs, and somatotropin improved symptoms of knee OA, it did not enhance cartilage regeneration significantly. This study highlights the potential of these combinations for symptom management but underscores the need for further research to optimize these therapies for regenerative outcomes.
Authors
- Bernadus Riyan Hartanto (ORCID: https://orcid.org/0000-0002-7236-794X)
- Anissa Feby Canintika (ORCID: https://orcid.org/0000-0003-4055-5417)
- Jacub Pandelaki (ORCID: https://orcid.org/0000-0003-2550-7206)
- Ismail Hadisoebroto Dilogo (ORCID: https://orcid.org/0000-0002-6202-0918)
- Irsa Gagah Himantoko (ORCID: https://orcid.org/0000-0002-0666-513X)
Institutions
- University of Indonesia (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-10-14
- DOI
- https://doi.org/10.3390/biomedicines12102332
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Indonesia