Organocatalytic Dearomatization of β‐Naphthols through a 1,6‐Conjugated Addition of Alkynyl 7‐Methylene‐7<i>H</i>‐indoles Formed In Situ
Abstract Organocatalytic dearomatization of β‐naphthols has been achieved via a 1,6‐conjugated addition of 2‐naphthols to alkynyl 7‐methylene‐7 H ‐indoles in situ generated from α‐(7‐indolyl)methanols. In the presence of racemic phosphoric acid, a series of tetrasubstituted allenes was obtained in high yields. Particularly, with the aid of chiral phosphoric acid, asymmetric dearomatization of β‐naphthols was investigated, affording axially chiral tetrasubstituted allenes with moderate enantioselectivity.
Authors
- Sheng-Jie Kang
- Xiaohong Liu (ORCID: https://orcid.org/0000-0003-4931-8370)
- Pengfei Li (ORCID: https://orcid.org/0000-0001-5836-1069)
- Fang Fang (ORCID: https://orcid.org/0009-0002-7382-7271)
- Wenjun Li (ORCID: https://orcid.org/0000-0002-6661-3518)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-6223-4724)
Institutions
- Qingdao University (CN)
- Southern University of Science and Technology (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/adsc.202401173
- Citations
- 5
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- Natural Science Foundation of Shandong Province
- Guangdong Provincial Key Laboratory Of Catalysis