Synthesis of CF<sub>3</sub>CH<sub>2</sub>‐Amides/Propiolamides/Acrylamides: The TfOH Catalyzed Reactions of Nitrile Compounds with CF<sub>3</sub>CHN<sub>2</sub>
Abstract An efficient and operationally simple protocol to access N ‐(2,2,2‐trifluoroethyl)amides/propiolamides and acrylamides via direct conversion of easily accessible nitriles (aryl/alkyl/alkynyl/vinyl) and in situ generated CF 3 CHN 2 as trifluoroethylating reagent has been developed. The protocol offers broad functional group tolerance under mild reaction conditions. Furthermore, the conversion of trifluoroethylated propiolamide into its triazole analog via Ru‐catalyzed [3+2] cycloadditions using BnN 3 clearly indicates its versatility in the synthetic applications.
Authors
- Avijit Goswami (ORCID: https://orcid.org/0000-0003-2798-1956)
- Madan Kumar
- Manisha Lamba (ORCID: https://orcid.org/0000-0001-5248-4295)
- Soni Devi
Institutions
- Indian Institute of Technology Ropar (IN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/adsc.202401120
- Primary Topic
- Organic and Inorganic Chemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Institute of Technology Ropar