Intratumoral STING agonist reverses immune evasion in PD-(L)1-refractory Merkel cell carcinoma: mechanistic insights from detailed biomarker analyses
Our results suggest that STING agonists may be able to work indirectly in MCC via signaling through immune and stromal cells in the TME, and may not necessarily need STING expression in the cancer cells. This approach may be particularly effective in tumors that are already infiltrated by inflammatory cells in the TME but are evading immune detection via HLA-I downregulation.
Authors
- Saumya Jani (ORCID: https://orcid.org/0000-0003-1212-1961)
- Shira Tabachnick‐Cherny (ORCID: https://orcid.org/0000-0003-1595-4619)
- David M. Koelle (ORCID: https://orcid.org/0000-0003-1255-9023)
- Candice D. Church (ORCID: https://orcid.org/0000-0003-1582-8292)
- Kimberly S. Smythe (ORCID: https://orcid.org/0000-0002-2329-8298)
- Brandon Seaton
- Rima M. Kulikauskas (ORCID: https://orcid.org/0000-0003-1092-1594)
- Shailender Bhatia (ORCID: https://orcid.org/0000-0002-3816-2238)
- Rashmi Bhakuni (ORCID: https://orcid.org/0000-0002-0450-3735)
- Thomas H. Pulliam (ORCID: https://orcid.org/0000-0003-3511-6348)
- Peter H. Goff (ORCID: https://orcid.org/0000-0002-3488-4997)
- Lisa Tachiki (ORCID: https://orcid.org/0000-0001-8057-8029)
- Paul Nghiem (ORCID: https://orcid.org/0000-0003-2784-963X)
Institutions
- University of Washington (US)
- University of Washington Medical Center (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/jitc-2024-009803
- Citations
- 9
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.54
Funders
- Bristol-Myers Squibb
- Pfizer
- Sanofi
- Fred Hutchinson Cancer Research Center
- University of Washington
- Regeneron Pharmaceuticals
- Incyte
- Seagen
- National Institutes of Health
- EMD Serono
- Sanofi Pasteur
- National Cancer Institute
- Office of Research Infrastructure Programs, National Institutes of Health