Metformin-mediated protection against doxorubicin-induced cardiotoxicity
We confirmed the MET-mediated protection against DOX-induced cardiomyocyte toxicity and its mechanism involving the inhibition of oxidative stress in vitro experiments. It is imperative to investigate the optimal conditions for MET-mediated protection against DOX-induced cardiotoxicity in vivo or clinical trials.
Authors
- Jie Zhen
- Ming‐Li Sun (ORCID: https://orcid.org/0000-0002-0535-2545)
- Pu Li (ORCID: https://orcid.org/0000-0002-5981-4119)
- Junfeng Dong (ORCID: https://orcid.org/0000-0003-2257-5983)
- Wei Chen (ORCID: https://orcid.org/0000-0002-0113-2596)
- Chen Liu (ORCID: https://orcid.org/0009-0000-7349-8610)
- Chao Zhang (ORCID: https://orcid.org/0009-0008-2674-344X)
Institutions
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1016/j.biopha.2024.117535
- Citations
- 11
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 4.42