An Improved Gold(I) Catalytic System for the Preparation of Coumarins <i>via</i> Intramolecular Cyclization
A catalytic system comprising a gold(I) complex with an N-heterocyclic carbene (NHC) ligand in an ionic liquid as solvent exhibits higher catalytic efficiency compared to state of the art systems in the title reaction, which enables using down to 0.01 mol % gold. A commercial gold(I) catalyst such as IPrAuNTf<sub>2</sub> can be employed for this purpose. In the case of less reactive substrates bearing electron-withdrawing substituents at the phenol moiety, a tailor made NHC-gold(I) precatalyst exhibits improved reactivity and can be advantageously employed compared to the commercial one.
Authors
- Marco Roverso (ORCID: https://orcid.org/0000-0003-1264-8878)
- Cristina Tubaro (ORCID: https://orcid.org/0000-0001-7724-735X)
- Riccardo Pedrazzani (ORCID: https://orcid.org/0000-0002-0586-3134)
- Andrea Biffis
- Marco Bandini (ORCID: https://orcid.org/0000-0001-9586-3295)
- Francesco Ravera
- Federico Floreani
Institutions
- University of Padua (IT)
- Consorzio Interuniversitario Reattività Chimica e Catalisi (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1002/asia.202400725
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Università degli Studi di Padova