CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
This study highlights the quantitative aspects underlying the creation of a platform for secreted heterologous EVs and shows the limits of single receptor-ligand interactions behind EV-cell engagement mechanisms, which now become the pivotal step to predict functional tropism and design new generations of EV-based nanovehicles.
Authors
- Michela Notarangelo (ORCID: https://orcid.org/0000-0003-3400-4440)
- Romina Belli
- Michela Roccuzzo (ORCID: https://orcid.org/0000-0002-0799-9369)
- Guido Jenster (ORCID: https://orcid.org/0000-0002-8658-2552)
- Vito D’Agostino (ORCID: https://orcid.org/0000-0003-3379-2254)
- Daniele Peroni (ORCID: https://orcid.org/0000-0002-0862-266X)
- Wenqiu Huang (ORCID: https://orcid.org/0000-0003-4904-746X)
- Michael Pancher (ORCID: https://orcid.org/0000-0002-3783-6069)
- Elena Gurrieri (ORCID: https://orcid.org/0000-0001-5645-1319)
- Timo L.M. ten Hagen
- Alessandro Quattrone (ORCID: https://orcid.org/0000-0003-3333-7630)
- Giulia Carradori
- Agata S. A. Carreira
- Caterina Trevisan (ORCID: https://orcid.org/0009-0000-6975-9152)
Institutions
- University of Trento (IT)
- Erasmus MC (NL)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s12929-024-01084-9
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- American-Italian Cancer Foundation
- Fondazione Cassa Di Risparmio Di Trento E Rovereto
- European Regional Development Fund