m6A-modified circXPO1 accelerates colorectal cancer progression via interaction with FMRP to promote WWC2 mRNA decay
m6A-modified circXPO1 by ALKBH5/IGF2BP2 axis destabilized WWC2 via interaction with FMRP to activate Hippo-YAP pathway, thereby facilitating CRC growth and metastasis. Targeting circXPO1 might be a potential therapeutic strategy for CRC.
Authors
- Pengxia Zhang (ORCID: https://orcid.org/0000-0003-0008-0357)
- Xiaowen Zhu (ORCID: https://orcid.org/0009-0009-0359-2682)
Institutions
- Jiamusi University (CN)
- First Affiliated Hospital of Jiamusi University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s12967-024-05716-4
- Citations
- 12
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.81