CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia
This is the first study assessing the potential of CT-based body composition analysis in patients with non-specific interstitial pneumonia (NSIP). A single-center analysis of 71 patients with board-certified diagnosis of NSIP is presented Indices related to muscle, mediastinal fat, and pulmonary fat attenuation volume were significantly associated with survival at univariate analysis. CT pulmonary fat attenuation volume, normalized by lung volume, resulted as an independent predictor for death.
Authors
- Luca Salhöfer (ORCID: https://orcid.org/0000-0002-5376-3154)
- Marcel Opitz (ORCID: https://orcid.org/0000-0001-7455-8590)
- Benedikt M. Schaarschmidt (ORCID: https://orcid.org/0000-0001-6331-7679)
- René Hosch (ORCID: https://orcid.org/0000-0003-1760-2342)
- Johannes Haubold (ORCID: https://orcid.org/0000-0003-4843-5911)
- Nikolas Beck (ORCID: https://orcid.org/0000-0002-5987-2351)
- Francesco Bonella (ORCID: https://orcid.org/0000-0001-7579-9767)
- Lale Umutlu (ORCID: https://orcid.org/0000-0001-5215-7171)
- Sebastian Zensen (ORCID: https://orcid.org/0000-0003-2997-0740)
- Vicky Parmar (ORCID: https://orcid.org/0000-0002-0383-0435)
- Michael Forsting (ORCID: https://orcid.org/0000-0002-5584-9824)
- Mathias Meetschen (ORCID: https://orcid.org/0000-0002-0719-2207)
- Felix Nensa (ORCID: https://orcid.org/0000-0002-5811-7100)
Institutions
- Essen University Hospital (DE)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s41747-024-00519-0
- Citations
- 3
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Deutsche Forschungsgemeinschaft