Oxidative Amidation of Ferrocenyl Aldehydes with Amines Catalyzed by Chalcogenised Fe₃Se₂(CO)₉ Cluster: Direct Transformation of Aldehyde to Amides

With the interest and knowing the importance of ferrocenyl conjugates, a direct amidation of ferrocenyl aldehyde has been developed under feasible conditions. Varieties of amines has been oxidatively coupled with ferrocene aldehyde in the presence of highly economical and robustly stable iron chalcogenide ironcarbonyl clusters [Fe₃E₂(CO)₉, E= S, Se, and Te] and TBHP. The reaction worked in greener solvent water at a moderate temperature of 70 °C and the ferrocenyl-amides in just 30 minutes. All the varieties of amines were found to be well tolerated for the present method, and due to the high medicinal importance of ferrocenyl-amides, sole focus of this report was concentrates on the synthesis of various new ferrocenyl-amides in good to excellent amounts.