Nanoemulsion is an effective antimicrobial for methicillin-resistant <i>Staphylococcus aureus</i> in infected swine skin burn wounds
The findings of this study are focused on therapeutic applications of nanotechnology. In the current study, we demonstrated that a nanoemulsion formulation could effectively kill methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infection in porcine skin burn wounds. Infection of MRSA in burn wound is a common threat to public health and is usually difficult to treat due to limited therapies available. NB-201 was effective in significantly alleviating inflammation in the treated wounds and promoting wound healing. Therefore, the finding of this study has a great potential to make this formulation a novel antimicrobial agent against MRSA.
Authors
- Jayme Cannon
- Zachary C. Meyer
- Su He Wang
- Jesse Chen (ORCID: https://orcid.org/0000-0002-7828-7019)
- James R. Baker (ORCID: https://orcid.org/0000-0002-4478-1932)
- Wenlu Ouyang (ORCID: https://orcid.org/0000-0002-0610-2118)
- Yongqing Li (ORCID: https://orcid.org/0000-0002-5152-7887)
- Zhengyi Cao
Institutions
- University of Michigan (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1128/spectrum.01378-24
- Citations
- 1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- U.S. Department of Defense
- Congressionally Directed Medical Research Programs