How condensed are mitotic chromosomes?
Chromosomes undergo dramatic compaction during mitosis, but accurately measuring their volume has been challenging. Employing serial block face scanning electron microscopy, Cisneros-Soberanis et al. (https://doi.org/10.1083/jcb.202403165) report that mitotic chromosomes compact to a nucleosome concentration of ∼760 µM.
Authors
- Hironori Funabiki (ORCID: https://orcid.org/0000-0003-4831-4087)
- Hideaki Konishi (ORCID: https://orcid.org/0000-0001-9529-9321)
Institutions
- Rockefeller University (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1083/jcb.202409044
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Stavros Niarchos Foundation
- National Institutes of Health
- Weill Cornell Medical College