Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
These findings report that the inhibition of Notch signaling by 2OHOA plays a role in its anti-tumoral activity, an effect that may be driven through direct inhibition of furin, characterizing a novel target of this bioactive lipid to treat GBM.
Authors
- Pablo V. Escribá (ORCID: https://orcid.org/0000-0001-9795-182X)
- Paula Fernández (ORCID: https://orcid.org/0000-0003-0140-7702)
- Roberto Beteta-Göbel (ORCID: https://orcid.org/0000-0002-4651-8433)
- Victoria Lladó
- Ramón Román (ORCID: https://orcid.org/0000-0003-2311-2737)
- Raquel Rodríguez-Lorca (ORCID: https://orcid.org/0000-0001-6027-0422)
- M. Torres (ORCID: https://orcid.org/0000-0002-5076-8486)
Institutions
- Hospital Comarcal de Inca (ES)
- Universitat de les Illes Balears (ES)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1007/s13402-024-00995-x
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- European Commission
- Ministerio de Economía y Competitividad
- Ministerio de Ciencia e Innovación
- Universitat de les Illes Balears
- Govern de les Illes Balears
- Horizon 2020 Framework Programme
- European Social Fund