Mitochondrial Dysfunction Associated with mtDNA Mutation: Mitochondrial Genome Editing in Atherosclerosis Research
The presence of the m.15059G>A mutation contributes to mitochondrial dysfunction by reducing mitochondrial membrane potential, increasing the generation of reactive oxygen species and lipid peroxidation, and altering mitochondrial bioenergetics. Elimination of the mtDNA containing atherogenic mutation leads to an improvement in mitochondrial function.
Authors
- Vasily N. Sukhorukov (ORCID: https://orcid.org/0000-0002-0312-3773)
- Vasily V. Sinyov (ORCID: https://orcid.org/0000-0001-5105-5763)
- Alexander D. Zhuravlev (ORCID: https://orcid.org/0000-0002-0451-2594)
- Igor A. Sobenin (ORCID: https://orcid.org/0000-0003-0978-6444)
- Andrey Yurievich Vinokurov (ORCID: https://orcid.org/0000-0001-8436-1353)
- Victoria A. Khotina (ORCID: https://orcid.org/0000-0003-2096-3237)
- Daniil Y. Popov (ORCID: https://orcid.org/0000-0002-9436-1346)
- Alexander N. Orekhov (ORCID: https://orcid.org/0000-0002-3318-4681)
Institutions
- Institute of Experimental Cardiology (RU)
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- Research Institute of Human Morphology (RU)
- National Medical Research Center of Cardiology (RU)
- Institute for Atherosclerosis Research (RU)
- Orel State University named after I.S. Turgenev (RU)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-10-14
- DOI
- https://doi.org/10.2174/0109298673323639240926095549
- Citations
- 7
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.64