Identifying transcription factors with cell-type specific DNA binding signatures
While recent results have highlighted cell state features such as chromatin accessibility and gene expression in predicting TF binding, our results emphasize that, for some TFs, the DNA sequences of the binding sites contain substantial cell-type specific motifs.
Authors
- Theodore J. Perkins (ORCID: https://orcid.org/0000-0002-6622-8003)
- Aseel Awdeh (ORCID: https://orcid.org/0000-0003-0578-090X)
- Marcel Turcotte (ORCID: https://orcid.org/0000-0002-4877-1029)
Institutions
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Ottawa Hospital Research Institute (CA)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s12864-024-10859-1
- Citations
- 5
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Queen Elizabeth Scholars
- Alliance de recherche numérique du Canada
- Natural Sciences and Engineering Research Council of Canada