Inhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models
These results show that inhibition of OXPHOS causes a metabolic shift from OXPHOS towards increased glycolysis in 2D and 3D cell culture. Moreover, inhibition of OXPHOS reduces diffusion limited hypoxia in 3D cell culture and murine tumor models. Reduced hypoxia by OXPHOS inhibition might enhance therapy efficacy in future studies. However, caution is warranted as systemic metabolic rewiring can cause adverse effects.
Authors
- Gosse J. Adema (ORCID: https://orcid.org/0000-0002-6750-1665)
- Johan Bussink (ORCID: https://orcid.org/0000-0002-5751-4796)
- Anne P.M. Beerkens
- Sandra Heskamp (ORCID: https://orcid.org/0000-0001-7250-0846)
- Milou Boswinkel
- Daan F. Boreel (ORCID: https://orcid.org/0000-0002-6025-1579)
- Paul N. Span (ORCID: https://orcid.org/0000-0002-1930-6638)
- Johannes Peters (ORCID: https://orcid.org/0000-0003-1964-6517)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1016/j.ctro.2024.100875
- Citations
- 7
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- KWF Kankerbestrijding