Annoglabrin A-C, three new ent-kaurane diterpenoids from the <i>Annona glabra</i> fruit pulp
Three new <i>ent</i>-kaurane diterpenoids, namely annoglabrin A-C (<b>1-3</b>), were isolated from the <i>Annona glabra</i> fruit pulp. Their structures were clarified by widespread spectroscopic analyses (1D and 2D NMR, HRESIMS). The relative configuration of these new compounds was established through the NOESY spectrum. Compounds <b>1-3</b> were evaluated for their inhibitory activity against <i>α-</i>glucosidase and were found with weak (<b>1</b> and <b>3</b>) or no effects (<b>2</b>), compared to those of positive control (acarbose, IC<sub>50</sub> 82.0 µM).
Authors
- Le-Thuy-Thuy-Trang Hoang (ORCID: https://orcid.org/0000-0001-9072-7083)
- Vo Thi Minh Thao
- Thanh-Nha Tran (ORCID: https://orcid.org/0000-0002-5693-3921)
- Ngoc-Van-Trang Dao
- Hien Quoc Ngo (ORCID: https://orcid.org/0000-0002-3367-2220)
- Van‐Kieu Nguyen (ORCID: https://orcid.org/0000-0001-9623-2735)
- Hoang-Vinh-Truong Phan (ORCID: https://orcid.org/0000-0003-0964-8025)
- Phan-Si-Nguyen Dong (ORCID: https://orcid.org/0000-0003-1683-0095)
- Xuan Thang Bui
- Dinh‐Tri Mai
- Minh-Khanh Nguyen (ORCID: https://orcid.org/0009-0009-9804-7387)
- Thi-Kim-Yen Duong
Institutions
- Ton Duc Thang University (VN)
- Duy Tan University (VN)
- Pham Ngoc Thach University of Medicine (VN)
- Ho Chi Minh City International University (VN)
- Department of Biotechnology (IN)
- Biotechnology Research Center (IR)
- Dalat University (VN)
- Bình Dương University (VN)
- Thu Dau Mot University
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1080/14786419.2024.2414397
- Citations
- 4
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 1.18