Exploring the link between sedentary behavior and cognitive decline: a comprehensive study combining Mendelian randomization and animal model experiments
Our research provides genetic evidence indicating that extended television viewing is linked to an elevated risk of cognitive decline. Additionally, experimental data from mouse models suggest that physical exercise can counteract cognitive decline and anxiety-like behaviors induced by sedentary behavior. This protective effect is likely mediated by reactive oxygen species (ROS)-dependent mechanisms that enhance synaptic plasticity within the hippocampus.
Authors
- Yan Fang (ORCID: https://orcid.org/0000-0001-6270-6058)
- Ruonan Zhan (ORCID: https://orcid.org/0000-0002-4261-265X)
- Ming Liu (ORCID: https://orcid.org/0000-0003-2508-4979)
- Yu Bai (ORCID: https://orcid.org/0009-0000-2439-3775)
Institutions
- Anhui Medical University (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Psychology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.3389/fpsyg.2024.1407846
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- National Natural Science Foundation of China
- Medical Research Council