The role of two major nucleoid-associated proteins in Streptomyces, HupA and HupS, in stress survival and gene expression regulation
We identify the independent HupA and HupS regulons, as well as genes under the control of both HupA and HupS proteins. Our data indicate a partial overlap between the functions of HupA and HupS during S. coelicolor growth. HupA and HupS play important roles in Streptomyces regulatory network and impact secondary metabolite clusters.
Authors
- Neil A. Holmes (ORCID: https://orcid.org/0000-0002-4979-9680)
- Dagmara Jakimowicz (ORCID: https://orcid.org/0000-0002-7857-064X)
- Jakub Mikołajczyk
- Agnieszka Strzałka (ORCID: https://orcid.org/0000-0002-7092-0609)
- Michał Skurczyński
- Klaudia Kowalska
Institutions
- John Innes Centre (GB)
- University of Wrocław (PL)
- Norwich Research Park (GB)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s12934-024-02549-0
- Citations
- 5
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.24