Long‐term hematopoietic dysfunction in patients with large‐scale mitochondrial DNA deletion syndromes
Our findings establish BM dysfunction as a persistent hallmark of SLSMD syndromes, posing a risk of clonal evolution and acquisition of chromosome 7 aberrations. This aligns with recent literature, emphasizing enduring BMF in SLSMD syndromes and advocating for tailored hematological monitoring guidelines for this unique patient cohort.
Authors
- Yair Anikster
- Amos Toren (ORCID: https://orcid.org/0000-0001-9909-8869)
- Corine Mardoukh
- Einat Lahav
- Liron D. Grossmann (ORCID: https://orcid.org/0000-0002-0692-8921)
- Noa Greenberg‐Kushnir (ORCID: https://orcid.org/0000-0002-9013-9537)
- Ginnete Schiby
- Yoav Bolkier (ORCID: https://orcid.org/0000-0002-2056-8790)
- Victoria Marcu‐Malina
- Assaf Arie Barg (ORCID: https://orcid.org/0000-0002-8329-8409)
- Noah Gruber (ORCID: https://orcid.org/0000-0002-2474-3250)
- Nira Varda‐Bloom
- Diana Bar (ORCID: https://orcid.org/0000-0001-9204-3857)
- Bella Bielorai (ORCID: https://orcid.org/0000-0003-3066-6439)
- Elad Jacoby (ORCID: https://orcid.org/0000-0003-1411-8942)
Institutions
- Children's Hospital of Philadelphia (US)
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- Edmond and Lily Safra Children's Hospital (IL)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1002/pbc.31383
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00