HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance
Our findings underscore HLA-G's role as a potential prognostic marker and interesting immunotherapeutic target in MIBC. Its impact on immune evasion mechanisms and broad expression, coupled with associations withpoor survival and distinct tumor phenotypes, positions HLA-G as a promising protein for further exploration in developing targeted immunotherapies for MIBC patients.
Authors
- Reiner Strick (ORCID: https://orcid.org/0000-0002-8141-7099)
- Michael Hölzel (ORCID: https://orcid.org/0000-0003-4048-8824)
- Barbara Seliger (ORCID: https://orcid.org/0000-0002-5544-4958)
- B. Wullich
- Arndt Hartmann (ORCID: https://orcid.org/0000-0002-4860-4626)
- Sven Wach (ORCID: https://orcid.org/0000-0003-4568-2490)
- Fabienne Lange (ORCID: https://orcid.org/0000-0003-2707-7676)
- Christian Matek (ORCID: https://orcid.org/0000-0001-8528-8581)
- Annalena Branz
- Niklas Klümper (ORCID: https://orcid.org/0000-0002-3258-0586)
- Markus Eckstein (ORCID: https://orcid.org/0000-0001-5418-3349)
- Helge Taubert
- Danijel Sikic
- Pamela L. Strissel
- Veronika Bahlinger
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Bonn (DE)
- Universitätsklinikum Erlangen (DE)
- Comprehensive Cancer Center Erlangen (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-14
- DOI
- https://doi.org/10.3389/fimmu.2024.1478196
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung