A Case Report on Methotrexate Overdose Induced Pancytopenia and Toxic Epidermal Necrolysis

Methotrexate is commonly used for autoimmune diseases including rheumatoid arthritis, psoriasis, sarcoidosis, and eczema due to its anti-inflammatory and immunosuppressive effect. The following report describes the case of a 48-year-old female presenting with complaints of fever, erythematous rash and blister over upper limb and oral hemorrhagic mucositis. She was previously diagnosed with rheumatoid arthritis and left sided poliomyelitis and was on methotrexate 15 mg weekly, but the patient had taken it daily resulting in toxicity. she was hospitalized, treated with folic acid, injection leucovorin & inj. filgrastim. Our case highlights the importance of counselling to ensure adherence to the correct methotrexate treatment regimen to prevent toxicity and its side effect.