The Effect of Royal Jelly Supplement on Frozen-Thawed Semen Quality and the Oxidant/Antioxidant Status

Background: This study aimed to investigate the effects of royal jelly on the quality of frozen-thawed semen and the oxidant/antioxidant status in men with sperm dysfunction due to reactive oxygen species. Methods: The research involved a total of 60 normospermic men, and their semen samples were divided into three groups: Fresh, frozen-thawed with added royal jelly, and frozen-thawed without royal jelly. Results: The findings showed that the addition of royal jelly increased the total antioxidants in frozen-thawed semen and reduced the levels of malondialdehyde (MDA), a marker of oxidative stress, compared to the group without royal jelly. Furthermore, the progressive sperm motility in the frozen-thawed semen with royal jelly was higher than in the group without royal jelly. Conclusions: These results suggest that royal jelly may have a positive impact on sperm motility and could be effective in reducing oxidative stress in frozen-thawed semen, thus potentially benefiting male fertility.