Evaluation of Minimum‐to‐Severe Global and Macrovesicular Steatosis in Human Liver Specimens: A Portable Ambient Light‐Compatible Spectroscopic Probe
Our study established the viability and reliability of a portable spectroscopic system for non-invasive HS and MaS assessment in human liver specimens. The compatibility with ambient light conditions and the ability to address limitations of previous methods marks a significant advancement in this field. By offering promising differentiation between global HS and MaS, our system introduces an innovative approach to real-time and quantitative donor HS assessments. The proposed method holds the promise of refining donor liver assessment during liver recovery and ultimately enhancing transplantation outcomes.
Authors
- Hao Guo (ORCID: https://orcid.org/0000-0003-3359-4514)
- Alexey B. Tikhomirov (ORCID: https://orcid.org/0000-0001-6123-5776)
- K. C. Hewitt (ORCID: https://orcid.org/0000-0002-6336-0789)
- Anita Mahadevan‐Jansen (ORCID: https://orcid.org/0000-0002-0491-3769)
- Haishan Zeng (ORCID: https://orcid.org/0000-0003-3557-2407)
- Andrea K. Locke (ORCID: https://orcid.org/0000-0002-7357-9688)
- Marten A. Engelse (ORCID: https://orcid.org/0000-0003-1341-8521)
- Ashley Stueck (ORCID: https://orcid.org/0000-0002-0328-6687)
- Ian P.J. Alwayn (ORCID: https://orcid.org/0000-0003-0603-9849)
- Boris Gala-López (ORCID: https://orcid.org/0000-0003-1179-2085)
- Jason B. Doppenberg (ORCID: https://orcid.org/0000-0001-7375-0839)
- Yun Suk Chae
Institutions
- Dalhousie University (CA)
- Vanderbilt University (US)
- Leiden University Medical Center (NL)
- Nova Scotia Health Authority (CA)
Publication Details
- Journal
- Journal of Biophotonics
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1002/jbio.202400292
- Citations
- 1
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.66
Funders
- Dalhousie University
- Research Nova Scotia