Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1G93A amyotrophic lateral sclerosis (ALS) mouse model
Our study provides further insights on the different roles of the TWEAK/Fn14 pathway in pathological skeletal muscle and how they can be influenced by age, disease, sex and exercise. This is particularly relevant in the ALS field, where combinatorial therapies that include exercise regimens are currently being explored. As such, a better understanding and consideration of the interactions between treatments, muscle metabolism, sex and exercise will be of importance in future studies.
Authors
- Cédric Raoul (ORCID: https://orcid.org/0000-0003-0561-6851)
- Gareth Hazell
- Eve McCallion
- Frédérique Scamps (ORCID: https://orcid.org/0000-0001-9545-407X)
- Emad I. H. Shaqoura
- Amarjit Bhomra (ORCID: https://orcid.org/0000-0002-0439-0128)
- Mélissa Bowerman (ORCID: https://orcid.org/0000-0002-3579-6403)
- Anna Kordala (ORCID: https://orcid.org/0000-0002-5363-1151)
- Nina Ahlskog (ORCID: https://orcid.org/0000-0002-3930-3928)
- Joseph M. Hoolachan (ORCID: https://orcid.org/0000-0002-8142-1469)
- Magnus Okoh
- Matthew J. A. Wood (ORCID: https://orcid.org/0000-0002-5436-6011)
- Taylor Scaife
- Sara Iqbal (ORCID: https://orcid.org/0000-0003-4027-1190)
- Emma R Sutton (ORCID: https://orcid.org/0009-0002-2127-6850)
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
- Robert Jones and Agnes Hunt Orthopaedic Hospital (GB)
- University of Oxford (GB)
- Institute for Neurosciences of Montpellier (FR)
- Hôpital Saint Eloi (FR)
- École Polytechnique Fédérale de Lausanne (CH)
- Keele University (GB)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1186/s13395-024-00356-0
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Biogen
- Academy of Medical Sciences
- University of Oxford
- Islamic University of Gaza
- Muscular Dystrophy UK
- Medical Research Council