Near‐Infrared Activatable Copper Nanoplatforms Synergize with the 5‐Azacytidine Prodrug to Potentiate Cuproptosis

Abstract Cuproptosis, a newly discovered cell death modality, is gaining recognition for its crucial role in antitumor therapy. Here, we demonstrated that Ferredoxin 1 (FDX1), a key gene involved in cuproptosis, is negatively correlated with malignancy and T‐cell exhaustion in head and neck squamous cell carcinoma (HNSCC). Based on these findings, we developed near‐infrared (NIR) light‐controlled nanoparticles (NPs), CuD@PM, which can selectively deliver copper to HNSCC cells and induce cuproptosis in the presence of microneedles loaded with triacetylated azacitidine (TAc‐AzaC) and 808 nm laser irradiation. Intravenous administration of these NPs significantly suppressed tumor growth in HNSCC animal models and enhanced the antitumor immune response. The NIR‐controlled activation of cuproptosis offers great potential as a safe, targeted, and image‐guided antitumor therapy for HNSCC.

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Publication Details

Journal
Angewandte Chemie
Published
2024-10-13
DOI
https://doi.org/10.1002/ange.202411609
Citations
2
Primary Topic
Advanced Nanomaterials in Catalysis
Type
article
Field-Weighted Citation Impact
0.23

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article

Near‐Infrared Activatable Copper Nanoplatforms Synergize with the 5‐Azacytidine Prodrug to Potentiate Cuproptosis

Zhi‐Jun Sun, Wuyin Wang, Wen-Da Wang, Yishen Liu et al.
2 citations
Angewandte Chemie
Advanced Nanomaterials in Catalysis
0.23
article

Near‐Infrared Activatable Copper Nanoplatforms Synergize with the 5‐Azacytidine Prodrug to Potentiate Cuproptosis

Zhi‐Jun Sun, Wuyin Wang, Wen-Da Wang, Yishen Liu, Zhiyun Zhang, Yuling Xiao, Xuechuan Hong, Qichao Yang, Yuanyuan Wang, Shuo Wang, Mengya Su
article en
2 citations

Abstract

Abstract Cuproptosis, a newly discovered cell death modality, is gaining recognition for its crucial role in antitumor therapy. Here, we demonstrated that Ferredoxin 1 (FDX1), a key gene involved in cuproptosis, is negatively correlated with malignancy and T‐cell exhaustion in head and neck squamous cell carcinoma (HNSCC). Based on these findings, we developed near‐infrared (NIR) light‐controlled nanoparticles (NPs), CuD@PM, which can selectively deliver copper to HNSCC cells and induce cuproptosis in the presence of microneedles loaded with triacetylated azacitidine (TAc‐AzaC) and 808 nm laser irradiation. Intravenous administration of these NPs significantly suppressed tumor growth in HNSCC animal models and enhanced the antitumor immune response. The NIR‐controlled activation of cuproptosis offers great potential as a safe, targeted, and image‐guided antitumor therapy for HNSCC.

Angewandte ChemieVol. 136(52)
Chinese Academy of Sciences (CN), Wuhan University (CN), Wuhan Institute of Virology (CN), Shanghai Institute of Materia Medica (CN), Zhongnan Hospital of Wuhan University (CN), State Key Laboratory of Virology
Natural Science Foundation of Shandong Province, National Key Research and Development Program of China, Basic and Applied Basic Research Foundation of Guangdong Province
Good health and well-being
Openalex Percentile: Top 51%
Advanced Nanomaterials in Catalysis
0.23
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