Reproductive safety of STING agonists MSA-2 and manganese-MSA-2
Results suggested that MSA-2 and MSA-2-Mn have negligible reproductive toxicity in healthy adults. Conclusions: This provides new ideas to enhance the efficacy of immunotherapy, as well as favorable evidence for future systemic dosing in patients of reproductive age and clinical trials of immunotherapy.
Authors
- Peng Zhou (ORCID: https://orcid.org/0000-0003-4285-7275)
- Tian Tian He (ORCID: https://orcid.org/0009-0004-2580-968X)
- Tao Yang (ORCID: https://orcid.org/0000-0003-4355-9210)
- Wenqing Li (ORCID: https://orcid.org/0000-0002-2460-7945)
- Ya Cai
- Lirong Yi (ORCID: https://orcid.org/0009-0009-0532-8690)
- Yating Li
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Institute of Reproductive Medicine (IN)
Publication Details
- Journal
- Toxicology Research
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1093/toxres/tfae172
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Nantong University