Validation study of risk-reduction activities after personalized breast cancer education tool in the WISDOM study

Breast cancer risk reduction strategies have been well-validated, but barriers remain for high-risk individuals to adopt them. We performed a study among participants with high risk of breast cancer to validate whether a virtual breast health decision tool impacted a participant's willingness to start risk-reducing activities, identify barriers to adopting these strategies, and understand if it affects breast cancer anxiety. The study sample was 318 participants in the personalized (investigational) arm of the Women Informed to Screen Depending on Measures of risk (WISDOM) clinical trial. After reviewing the tool, these participants completed a feedback survey. We demonstrated that 15 (4.7%) women were taking endocrine risk reduction, 123 (38.7%) were reducing alcohol intake, and 199 (62.6%) were exercising. In the three-month follow-up survey of 109 respondents, only 8 of 61 (13.1%) women who considered endocrine risk reduction pursued it. In contrast, 11 of 16 (68%) participants who considered alcohol reduction pursued the activity, and 14 of 24 (58%) women who considered exercise followed through. Participants listed fear of side effects as the most common barrier to endocrine risk reduction. We also present further steps to be taken to improve the effectiveness of the Breast Health Decisions tool.

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Publication Details

Journal
npj Breast Cancer
Published
2024-10-13
DOI
https://doi.org/10.1038/s41523-024-00681-z
Citations
3
Primary Topic
BRCA gene mutations in cancer
Type
article
Field-Weighted Citation Impact
1.65

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article

Validation study of risk-reduction activities after personalized breast cancer education tool in the WISDOM study

Yash S. Huilgol, Celia P. Kaplan, Leah Sabacan, Laura van ‘t Veer et al.
3 citations
npj Breast Cancer
BRCA gene mutations in cancer
1.65
article

Validation study of risk-reduction activities after personalized breast cancer education tool in the WISDOM study

Yash S. Huilgol, Celia P. Kaplan, Leah Sabacan, Laura van ‘t Veer, Andrea Kaster, Steffanie Goodman, Irene Acerbi, Jeffrey A. Tice, Yiwey Shieh, Amie Blanco, Jeffrey Belkora, Diane Heditsian, Diana DeRosa, Kenneth Wimmer, Rachael Lancaster, John F. Pierce, Kim F. Rhoads, Rashna Soonavala, Kimberly Badal, Jan Wernisch, Mandy Che, Tracy M. Layton, Skye Stewart, Patricia Choy, Barry Tong, Antonia Petruse, Holly Keane, Barbara A. Parker, Stephanie Flores, Katherine Ross, D Morehead, Elad Ziv, Annette L. Stanton, Tomiyuri Lewis, Christina Yau, Katherine Leggat-Barr, Kelly Adduci, Vivian Lee, Alexander D. Borowsky, Deborah Goodman, Laura J. Esserman, Arash Naeim, Martin Eklund, Michael Hogarth, Andrea Z. LaCroix, Neil S. Wenger, Hoda Anton‐Culver, Sheri J. Hartman, Lisa Madlensky, Carlie K. Thompson, Hannah Lui Park, Karen Sepucha, Elissa M. Ozanne, Allison Stover Fiscalini, Roxanna Firouzian, Tianyi Wang, Lydia Howell, Robert Hiatt, Maren Scheuner-Purcell, James Esserman, Olufunmilayo Olopade, Susie Brain
article en
3 citations

Abstract

Breast cancer risk reduction strategies have been well-validated, but barriers remain for high-risk individuals to adopt them. We performed a study among participants with high risk of breast cancer to validate whether a virtual breast health decision tool impacted a participant's willingness to start risk-reducing activities, identify barriers to adopting these strategies, and understand if it affects breast cancer anxiety. The study sample was 318 participants in the personalized (investigational) arm of the Women Informed to Screen Depending on Measures of risk (WISDOM) clinical trial. After reviewing the tool, these participants completed a feedback survey. We demonstrated that 15 (4.7%) women were taking endocrine risk reduction, 123 (38.7%) were reducing alcohol intake, and 199 (62.6%) were exercising. In the three-month follow-up survey of 109 respondents, only 8 of 61 (13.1%) women who considered endocrine risk reduction pursued it. In contrast, 11 of 16 (68%) participants who considered alcohol reduction pursued the activity, and 14 of 24 (58%) women who considered exercise followed through. Participants listed fear of side effects as the most common barrier to endocrine risk reduction. We also present further steps to be taken to improve the effectiveness of the Breast Health Decisions tool.

npj Breast CancerVol. 10(1)
Rush University Medical Center (US), Sanford Health (US), University of California, Los Angeles (US), University of California, San Francisco (US), University of California, Irvine (US), Cornell University (US), University of Utah (US), University of Michigan (US), Peter MacCallum Cancer Centre (AU), Karolinska Institutet (SE), University of Alabama at Birmingham (US), University of California San Diego (US), University of Illinois Chicago (US), University of Chicago (US), Massachusetts General Hospital (US), Wisdom Health (United States) (US), Clinical Pharmacology of Miami (US), Weill Cornell Medicine (US), University of San Francisco (US), University of California, Davis (US)
Breast Cancer Research Foundation, Patient-Centered Outcomes Research Institute, Office of the President, University of California, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 14%
BRCA gene mutations in cancer
1.65
DOIOpen Access PDFOpenAlex
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