Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas
Patients with adrenal aldosterone-producing adenomas (APA) face elevated cardiovascular risks, especially when cortisol is co-secreted, yet the impact on muscle health remains unclear. Myosteatosis, characterized by fatty infiltration into muscles, is linked to cardiometabolic diseases and decreased survival. We aimed to investigate the association between autonomous cortisol secretion (ACS) in APA and muscle quantity and quality. In this study, we analyzed data from 228 APA patients undergoing laparoscopic adrenalectomy between 2009 and 2024, assessing muscle composition via computed tomography. Intermuscular adipose tissue (IMAT), skeletal muscle area and density, visceral and subcutaneous adipose tissue area at L3 were measured. Comparisons were made between ACS and non-ACS groups. We found that among 228 patients, 76 (33.3%) had ACS. Those with ACS exhibited significantly higher IMAT area (P = 0.042) and lower skeletal muscle area (P = 0.002) and density (P < 0.001). Multivariable regression confirmed ACS positively associated with IMAT area and negatively associated with skeletal muscle area and density. At 1-year follow-up, ACS patients (n = 15) experienced decreased IMAT area (P = 0.001) and increased skeletal muscle area (P = 0.031) post-adrenalectomy, while those without ACS (n = 29) showed no IMAT change but increased visceral (P < 0.001) and subcutaneous (P = 0.008) adipose tissue area. In summary, myosteatosis and sarcopenia are linked to ACS in APA patients, and these parameters improve following adrenalectomy.
Authors
- Chin‐Chen Chang (ORCID: https://orcid.org/0000-0002-0121-4866)
- Chieh‐Kai Chan (ORCID: https://orcid.org/0000-0003-4529-3161)
- Shao‐Yu Yang (ORCID: https://orcid.org/0000-0001-9170-2566)
- Wei‐Chieh Huang (ORCID: https://orcid.org/0000-0003-3759-0131)
- Yen‐Hung Lin (ORCID: https://orcid.org/0000-0001-8153-1441)
- Vin‐Cent Wu (ORCID: https://orcid.org/0000-0001-7935-0991)
- Tai‐Shuan Lai (ORCID: https://orcid.org/0000-0002-0552-372X)
- Shih‐Cheng Liao (ORCID: https://orcid.org/0000-0003-4129-0879)
- Kuo‐How Huang (ORCID: https://orcid.org/0000-0002-0989-0578)
- Chien‐Ting Pan (ORCID: https://orcid.org/0000-0002-5757-7690)
- Shuo‐Meng Wang (ORCID: https://orcid.org/0000-0003-2090-1757)
- Che‐Wei Liao (ORCID: https://orcid.org/0000-0001-7156-5381)
- Yahui Hu (ORCID: https://orcid.org/0000-0002-9856-5485)
- Bo‐Ching Lee (ORCID: https://orcid.org/0000-0002-1443-928X)
- Yu‐Ling Chang (ORCID: https://orcid.org/0000-0002-0789-4989)
- Po‐Chih Lin (ORCID: https://orcid.org/0000-0003-1083-4415)
- Zheng‐Wei Chen (ORCID: https://orcid.org/0000-0001-7728-6674)
- Cheng‐Hsuan Tsai (ORCID: https://orcid.org/0000-0003-2859-5117)
- Yao‐Chou Tsai (ORCID: https://orcid.org/0000-0002-2833-5609)
- Leay‐Kiaw Er
- Kao‐Lang Liu (ORCID: https://orcid.org/0000-0003-4100-8909)
- Che‐Hsiung Wu (ORCID: https://orcid.org/0000-0001-6164-6655)
- Shih‐Chieh Chueh (ORCID: https://orcid.org/0000-0002-0713-4904)
- Liwen Liu (ORCID: https://orcid.org/0000-0003-2577-7791)
- Yung‐Ming Chen (ORCID: https://orcid.org/0000-0002-9241-1258)
- Po‐Ting Chen
- Ching-Chu Lu
- Chi-Sheng Hung
- Yi-Yao Chang
- Chen‐Hsun Ho
Institutions
- National Taiwan University (TW)
- Mackay Memorial Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Hypertension Research
- Published
- 2024-10-14
- DOI
- https://doi.org/10.1038/s41440-024-01933-y
- Citations
- 5
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- Ministry of Science and Technology, Taiwan
- National Taiwan University Hospital
- National Taiwan University