A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation
NFEPP did not exhibit tolerance in an inflammatory pain model, unlike fentanyl. Consequently, dose escalation to maintain analgesia during an evolving inflammation could be avoided, mitigating the potential risk of side effects.
Authors
- Christoph Stein (ORCID: https://orcid.org/0000-0001-5240-6836)
- H M Schincariol
- David E. Reed (ORCID: https://orcid.org/0000-0003-1802-4863)
- Stephen Vanner (ORCID: https://orcid.org/0000-0002-4006-9948)
- Alan Lomax (ORCID: https://orcid.org/0000-0003-4743-9929)
- Mabel Guzmán-Rodríguez
- Claudius E. Degro (ORCID: https://orcid.org/0000-0001-9066-5388)
- Nigel W. Bunnett (ORCID: https://orcid.org/0000-0003-3367-0644)
- Nestor N. Jiménez-Vargas (ORCID: https://orcid.org/0000-0001-6595-1884)
- Quentin Tsang (ORCID: https://orcid.org/0000-0002-9841-3115)
Institutions
- Neurosciences Institute (US)
- Queen's University (CA)
- Kingston General Hospital (CA)
- Humboldt-Universität zu Berlin (DE)
- New York University (US)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-10-13
- DOI
- https://doi.org/10.1111/bph.17363
- Citations
- 5
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- U.S. Department of Defense
- Crohn's and Colitis Foundation
- Crohn's and Colitis Foundation of Canada
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Crohn's and Colitis Canada
- National Institutes of Health